Methotrexate
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB00563 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 100 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | pulmonary blastoma | KG + DL |
| 2 | primary pulmonary lymphoma | KG + DL |
| 3 | small cell lung carcinoma | KG + DL |
| 4 | well-differentiated fetal adenocarcinoma of the lung | KG + DL |
| 5 | Hodgkins lymphoma | KG + DL |
| 6 | rhabdomyosarcoma (disease) | KG + DL |
| 7 | pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma | KG + DL |
| 8 | chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation | KG + DL |
| 9 | parameningeal embryonal rhabdomyosarcoma | KG + DL |
| 10 | botryoid-type embryonal rhabdomyosarcoma of the vagina | KG + DL |
| 11 | embryonal extrahepatic bile duct rhabdomyosarcoma | KG + DL |
| 12 | extrahepatic bile duct rhabdomyosarcoma | KG + DL |
| 13 | prostate embryonal rhabdomyosarcoma | KG + DL |
| 14 | brachydactyly-syndactyly syndrome | KG + DL |
| 15 | liver sarcoma | KG + DL |
| 16 | colobomatous microphthalmia-rhizomelic dysplasia syndrome | KG + DL |
| 17 | unclassified myelodysplastic syndrome | KG + DL |
| 18 | aregenerative anemia | KG + DL |
| 19 | refractory cytopenia of childhood | KG + DL |
| 20 | severe congenital hypochromic anemia with ringed sideroblasts | KG + DL |
| 21 | partial deletion of the long arm of chromosome 5 | KG + DL |
| 22 | myelodysplastic syndrome | KG + DL |
| 23 | acute lymphoblastic leukemia | KG + DL |
| 24 | myeloid leukemia | KG + DL |
| 25 | ALK-positive large B-cell lymphoma | KG + DL |
| 26 | precursor lymphoblastic lymphoma/leukemia | KG + DL |
| 27 | obsolete Hodgkin’s granuloma | KG + DL |
| 28 | ganglioneuroblastoma (disease) | KG + DL |
| 29 | small intestine lymphoma | KG + DL |
| 30 | adenosarcoma | KG + DL |
| 31 | neuroblastoma | KG + DL |
| 32 | monocytic leukemia | KG + DL |
| 33 | classic Hodgkin lymphoma | KG + DL |
| 34 | lymphoid neoplasm | KG + DL |
| 35 | neonatal jaundice | KG + DL |
| 36 | ectodermal dysplasia and immunodeficiency | KG + DL |
| 37 | classic Hodgkin lymphoma, lymphocyte-depleted type | KG + DL |
| 38 | retroperitoneal neoplasm | KG + DL |
| 39 | systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood | KG + DL |
| 40 | lung mixed small cell and squamous cell carcinoma | KG + DL |
| 41 | hydroa vacciniforme-like lymphoma | KG + DL |
| 42 | classic Hodgkin lymphoma, mixed cellularity type | KG + DL |
| 43 | thymic epithelial neoplasm | KG + DL |
| 44 | Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly | KG + DL |
| 45 | Hodgkin’s lymphoma, mixed cellularity | KG + DL |
| 46 | 2q33.1 microdeletion syndrome | KG + DL |
| 47 | nodular lymphocyte predominant Hodgkin lymphoma | KG + DL |
| 48 | vertebral anomalies and variable endocrine and T-cell dysfunction | KG + DL |
| 49 | Hodgkin’s lymphoma, lymphocytic-histiocytic predominance | KG + DL |
| 50 | uterine ligament adenosarcoma | KG + DL |
(Showing top 50 of 100 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.