Larotrectinib
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB14723 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 100 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | multiple endocrine neoplasia | KG + DL |
| 2 | HER2 positive breast carcinoma | KG + DL |
| 3 | cytomegalovirus infection | KG + DL |
| 4 | malignant catarrh | KG + DL |
| 5 | infectious bovine rhinotracheitis | KG + DL |
| 6 | progesterone-receptor negative breast cancer | KG + DL |
| 7 | progesterone-receptor positive breast cancer | KG + DL |
| 8 | normal breast-like subtype of breast carcinoma | KG + DL |
| 9 | breast tumor luminal A or B | KG + DL |
| 10 | thrombocytopenia | KG + DL |
| 11 | pulmonary hypertension | KG + DL |
| 12 | marcothrombocytopenia with mitral valve insufficiency | KG + DL |
| 13 | hereditary thrombocytopenia with normal platelets | KG + DL |
| 14 | transient neonatal thrombocytopenia | KG + DL |
| 15 | dense granule disease | KG + DL |
| 16 | amyotrophic lateral sclerosis | KG + DL |
| 17 | kyphoscoliotic heart disease | KG + DL |
| 18 | homozygous familial hypercholesterolemia | KG + DL |
| 19 | amenorrhea (disease) | KG + DL |
| 20 | hyperthyroidism | KG + DL |
| 21 | female breast carcinoma | KG + DL |
| 22 | thrombotic disease | KG + DL |
| 23 | amyotrohpic lateral sclerosis type 22 | KG + DL |
| 24 | amyotrophic lateral sclerosis, susceptibility to | KG + DL |
| 25 | axial spondylometaphyseal dysplasia | KG + DL |
| 26 | Mills syndrome | KG + DL |
| 27 | resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta | KG + DL |
| 28 | trichomegaly-retina pigmentary degeneration-dwarfism syndrome | KG + DL |
| 29 | lethal arthrogryposis-anterior horn cell disease syndrome | KG + DL |
| 30 | bilateral parasagittal parieto-occipital polymicrogyria | KG + DL |
| 31 | neuroblastoma | KG + DL |
| 32 | lower motor neuron syndrome with late-adult onset | KG + DL |
| 33 | adrenal gland hyperfunction | KG + DL |
| 34 | platelet storage pool deficiency | KG + DL |
| 35 | secondary dysgenetic glaucoma associated with neural crest cell migration anomaly | KG + DL |
| 36 | Prinzmetal angina | KG + DL |
| 37 | myeloid leukemia | KG + DL |
| 38 | monomelic amyotrophy | KG + DL |
| 39 | ganglioneuroblastoma (disease) | KG + DL |
| 40 | vertebral anomalies and variable endocrine and T-cell dysfunction | KG + DL |
| 41 | stroke disorder | KG + DL |
| 42 | collagenopathy | KG + DL |
| 43 | lymphocytic hypereosinophilic syndrome | KG + DL |
| 44 | retroperitoneal neoplasm | KG + DL |
| 45 | hereditary neuroendocrine tumor of small intestine | KG + DL |
| 46 | HIV infectious disease | KG + DL |
| 47 | vein disease | KG + DL |
| 48 | autosomal dominant mitochondrial myopathy with exercise intolerance | KG + DL |
| 49 | Leydig cell hypoplasia due to LH resistance | KG + DL |
| 50 | 46,XY disorder of sex development due to impaired androgen production | KG + DL |
(Showing top 50 of 100 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.